The endocannabinoid system is known to play an important role in regulating immunity and scientists consider it to be one of the “gatekeepers” of the immune system.1 The endocannabinoid system includes receptors known as cannabinoid receptors 1 and 2 (CB1 and CB2) as well as the endogenous cannabinoids anandamide (AEA) and 2-arachidonoylglycerol (2-AG) and enzymes that influence the production of these endocannabinoids.
There’s scientific evidence that cells of the immune system express both CB1 and CB2, although CB2 concentrations are higher than CB1.2